Antimicrobial resistance (AMR) is a global health security and development challenge that poses a threat to public health and economic prosperity. It is a challenge that is often overlooked. As antimicrobials have become part of the infrastructure of modern society, it has become all too easy to take them for granted; but their longevity is under threat. Antimicrobials and antibiotics are widely used for health, industrial, and agricultural purposes. In health care, they are inextricably linked to the advances in modern public health that societies have witnessed in recent decades. They have become a go-to medication for a variety of infections, from strep throat to sepsis. They have also become essential to agricultural and food systems and are used in crop and livestock management. Nevertheless, inappropriate use of antimicrobials threatens their sustainability, and the devastating impact of this development, in which the drugs we know and rely on cease to work, is already emerging. In 2019, an estimated 4.95 million deaths were associated with bacterial AMR, more than the number of deaths attributed to AIDS, HIV, and malaria—making AMR one of the world’s biggest killers (Antimicrobial Resistance Collaborators 2022). The impact of AMR is not limited to human health. In 2017, the World Bank estimated that by 2050, unchecked AMR could wipe away 3.8 percent of global gross domestic product each year and push 28 million people into poverty (World Bank 2017).